Table 1.
Model parameter inputs
| Parameter description | Best Estimate (95% CI) | Probability distribution | Source |
|---|---|---|---|
| PCD prevalence among suspect patients | 0.32 (0.25–0.39) | Normal (μ: 0.32, SD:0.028) | [32] |
| Diagnostic Accuracy | |||
| nNO (VC) sensitivity | 0.95 (0.91–0.97) | Beta (a: 0.95, b: 0.05) | [33] |
| nNO (VC) specificity | 0.94 (0.88–0.97) | Beta (a: 0.94, b: 0.06) | [33] |
| TEM sensitivity | 0.74 (0.66–0.83) | Beta (a: 0.74, b: 0.26) | [32] |
| TEM specificity | 0.91 (0.86–0.96) | Beta (a: 0.91, b: 0.09) | [32] |
| HSVM sensitivity | 1.00 (0.89–1.00) | Beta (a: 0.99, b: 0.01) | [34, 35] |
| HSVM specificity | 0.92 (0.86–0.96) | Beta (a: 0.92, b: 0.08) | [34] |
| Diagnostic Costs | |||
| nNO related cost parameters) | |||
| nNO Ecomedics CLD88sp (VC) capital cost (€) | 40,000 (36,000–44,000) | Gamma (μ: 40,000) | Market Value |
| nNO Ecomedics CLD88sp (VC) consumables per patient (€) | 15 (9–21) | Gamma (μ: 15) | Market Value |
| nNO operators rate (€/hour) | 25 (10–35) | Gamma (μ: 25) | Eurostat |
| nNO Ecomedics CLD88sp (VC) test duration (hours) | 0.5 (0.3–0.7) | Normal (μ: 0.5, SD: 0.1) | Based on ATS/ERS [19] |
| nNO Ecomedics CLD88sp equipment lifespan (years) | 15 (13–17) | Normal (μ: 15, SD: 1) | Market Value |
| nNO Ecomedics CLD88sp (VC) annual maintenance (€) | 1300 (1100–1500) | Gamma (μ: 1300) | Market Value |
| HSVM related cost parameters | |||
| Capital cost HSVM – SAVA system (€) | 5000 (3000–7000) | Gamma (μ: 5000) | Market Value (incl. Camera and software) |
| HSVM consumables (€) | 30 (26–34) | Gamma (μ: 30) | Market Value |
| HSVM operators rate (€/hour) | 25 (10–35) | Gamma (μ: 25) | Eurostat |
| HSVM equipment lifespan (years) | 15 (10–20) | Normal (μ: 15, SD: 2) | Assumption |
| HSVM test duration (hours) | 2 (1.6–2.4) | Normal (μ: 2, SD: 0.2) | Based on Sisson J 2003 [17] |
| TEM related cost parameters | |||
| TEM capital cost (€) | 100,000 (90,000–110,000) | Gamma (μ:100,000) | Market Value |
| TEM consumables (€) | 120 (90–140) | Gamma (μ:120) | Market Value |
| Brushing Time (hours) | 0.2 (−) | Constant: (Brushing Time: 0.2) | Assumption |
| TEM operators rate (€/hour) | 25 (10–35) | Gamma (μ: 25) | Eurostat |
| TEM test duration (hours) | 10 (6–18) | LogNormal (Median: 10, gsd: 1.3) | [12, 35] |
| TEM equipment lifespan (years) | 30 (20–40) | Normal (μ: 30, SD: 5) | Assumption |
| Physician’s rate (€/hour) | 50 (30–70) | Gamma (μ: 50) | Eurostat |
| TEM annual maintenance (€) | 2000 (1300–2600) | Gamma (μ: 2000) | Assumption |