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. 2019 Jun 7;10:1282. doi: 10.3389/fimmu.2019.01282

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Copyright © 2019 Puraswani, Khandelwal, Saini, Saini, Gurjar, Sinha, Shende, Maiti, Singh, Kanga, Ali, Agarwal, Anand, Prasad, Rajendran, Sinha, Vasudevan, Saxena, Agarwal, Hari, Sahu, Rath and Bagga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Mean anti-factor H (FH) antibody titers, and (B) Free FH during remission in patients with or without subsequent relapse. Relapses were seen in 12 of 182 (A) and 10 of 44 (B) patients. Generalized estimating equations approach was used on log transformed data. In patients with relapse, the last anti-FH titer and free FH was estimated at median of 1 (0.7–2) months and 5 (2–6.9) months before relapse, respectively. Anti-FH antibody titers ≥1,330 AU/ml or free FH ≤ 440 mg/l predict later relapse.