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. 2019 Jun 7;10:1266. doi: 10.3389/fmicb.2019.01266

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Copyright © 2019 Zeng, Zhang, Chen, Long, Lu and Sang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ITC-VER combination is the most promising candidate among antifungal drugs and calcium channel blockers (CCBs) against Aspergillus spp. (A) Testing the growth inhibition on agar plates by itraconazole (ITC) (0.1 μg/ml) with different CCBs, including verapamil (VER), nifedipine (NFD) and diltiazem (DTZ), at 200 μg/ml against an A. fumigatus stain. (B) Testing the growth inhibition on agar plates by VER (600 μg/ml) with different antifungal drugs (AFD), including ITC (0.1 μg/ml), voriconazole (VRC) (0.05 μg/ml) and amphotericin B (AMB) (1.5 μg/ml), against an A. fumigatus stain. (C) Testing the growth inhibition on agar plates by the ITC-VER combination against A. fumigatus (0.1 and 200 μg/ml, respectively), A. flavus (0.04 and 50 μg/ml, respectively), A. terreus (0.1 and 50 μg/ml, respectively) and A. niger (0.1 and 600 μg/ml, respectively).