Table 1.

Antifungal susceptibility testing and drug interaction evaluation between ITC and VER against A. fumigatus.

Strain	MIC (μg/ml)
	Alone		Combined		ITC-VER interaction
	ITC	VER	ITC	VER	FICI	Interpretationa
Afc03‡	0.25	> 9600	0.0625	40	< 0.254	SYN
Afc06‡	0.25	> 9600	0.0625	40	< 0.254	SYN
Afc07‡	0.25	> 9600	0.0625	80	< 0.258	SYN
Afc18‡	0.5	> 9600	0.125	80	< 0.258	SYN
Af1161	0.25	> 9600	0.0625	80	< 0.258	SYN
Af293	0.25	> 9600	0.25	80	< 1.008	NI
Shjt40†	8	> 9600	1	960	< 0.225	SYN
Shjt42b†	16	> 9600	16	960	< 1.1	NI
Afc3-339	16	> 9600	4	480	< 0.3	SYN
Afc6-75	2	> 9600	0.25	480	< 0.175	SYN
Afc7-233	16	> 9600	16	960	< 1.1	NI
Af1161-73	16	> 9600	4	480	< 0.3	SYN
Af1161-132	8	> 9600	2	960	< 0.35	SYN
Af1161-78	16	> 9600	2	960	< 0.225	SYN
Af1161-185	16	> 9600	4	480	< 0.3	SYN
Af1161-331	16	> 9600	2	960	< 0.225	SYN
Af1161-353	16	> 9600	8	960	< 0.6	NI

^aAbbreviations: FICI, fractional inhibitory concentration index; ITC, itraconazole; NI, no interaction; SYN, synergism; VER, verapamil. ^‡Clinical-derived isolates susceptible to itraconazole. ^†Clinical-derived isolates resistant to itraconazole (8).