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. 2019 May 24;9(11):3388–3397. doi: 10.7150/thno.34031

Figure 2.

Figure 2

A) Schematic of the immune study of naive mice. B) The percentage of vaccinated mice without tumorigenesis after challenge with B16-OVA cells on day 28; the data were analyzed by the log-rank test (** p < 0.01, 3DSNA+OVA compared with PBS, OVA, Alum+OVA; * p < 0.05, 3DSNA+OVA compared with 3LSNA+OVA, n = 5). C) Average tumor volume of vaccinated mice inoculated with B16-OVA cells on day 28; the data were analyzed by two-way ANOVA (**** p < 0.0001, 3DSNA+OVA compared with PBS, OVA, Alum+OVA and 3LSNA+OVA, n = 5). D) The representative pictures of tumor-bearing mice at day 18. E) The survival of vaccinated mice after inoculation with B16-OVA cells; the data were analyzed by the log-rank test (** p < 0.01, 3DSNA+OVA compared with PBS, OVA, Alum+OVA and 3LSNA+OVA, n = 5).