Figure 4.

Scheme of the synthesis of the mechanized nanoparticles and their operation under oscillating magnetic fields (OMFs). (1) Supraparamagnetic nanoparticles are synthetically positioned at the core of MSNs; (2) the molecular machine is then attached to the nanoparticle's surface; (3) the drug is loaded into the particle and (4) the pores are capped to complete the system. (5) Drug release is realized using remote heating via an OMF. Reprinted with permission from ²⁵, copyright (2010) J. Am. Chem. Soc.