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A comprehensive view of the factors involved in the process of browning. Exercise has beneficial effects on browning but many other factors are also promoted according to physical activity such as (I) beta aminoisobutyric acid (BAIBA); (2) gamma aminobutyric acid (GABA); (3) IRISIN; (4) fibroblast growth factor 21 (FGF2I); and (5) musclin (PPARγ agonist). Beside all these factors cold exposure can lead to browning through UCPI. The possible mechanisms involve lipogenic pathways.
