Table 1.
Clinical and demographic characteristics stratified by age.
| Variable (n (%) unless stated otherwise) | Age <18 (n=33) | Age ≥18 (n=136) | p-value |
|---|---|---|---|
| Age (mean (median) ± std dev) | 15.7 (16.0) ± 1.6 | 29.1 (27.2) ± 8.9 | <0.0001 |
| Height (cm, mean (median) ± std dev) | 161 (161.8) ± 10 | 166.8 (165.1) ± 9.5 | 0.002 |
| Duration of IV treatment (mean (median) ± std dev) | 14 (15.0) ± 4.2 | 15.7 (15.0) ± 5.4 | 0.20 |
| Missing | 3 | 8 | |
| Any IV therapy after completion of initial therapy | 18 (60%) | 80 (63%) | 0.80 |
| Missing | 3 | 8 | |
| ppFEV1 (mean (median) ± std dev); (n): | |||
| ±3 Days from Index Date | 69.7% (70.5%) ± 21.0% (29) | 47.3% (44.7%) ± 19.6% (136) | <0.0001 |
| ±3 Days from End of Tx day | 81.4% (85.7%) ± 21% (26) | 56.4% (54.1%) ± 22.0% (99) | <0.0001 |
| Change in FEV1 % Predicted from Index Date to End of Tx (± 3 days) | 14.5% (11.3%) ± 17.5% (24) | 7.6% (7.4%) ± 7.8% (96) | 0.07 |
| Female | 19 (58%) | 81 (60%) | 0.84 |
| Race | |||
| White | 31 (94%) | 131 (96%) | |
| Black | 2 (6%) | 3 (2%) | |
| Asian | 0 | 0 | 0.40 |
| Two or more races | 0 | 2 (1%) | |
| Hispanic | 3 (10%) | 5 (4%) | 0.18 |
| Unknown | 2 | 6 | |
| What type of insurance did the patient have?1 | |||
| Private | 20 (61%) | 76 (56%) | 0.65 |
| Medicare | 1 (3%) | 35 (26%) | 0.004 |
| Medicaid | 18 (55%) | 47 (35%) | 0.04 |
| State special needs | 4 (12%) | 11 (8%) | 0.47 |
| Military | 1 (3%) | 7 (5%) | 0.60 |
| Other | 1 (3%) | 7 (5%) | 0.60 |
| Missing | 0 | 1 | |
| Patient covered under his/her parent’s insurance | 21 (66%) | 33 (28%) | <0.0001 |
| Missing | 1 | 19 | |
| Patient covered under a patient assistance program | 6 (24%) | 23 (25%) | 0.93 |
| Missing | 8 | 43 | |
| Patient education | |||
| <High school | 32 (97%) | 9 (7%) | |
| High school diploma | 1 (3%) | 36 (28%) | |
| Some college | 0 | 44 (34%) | <0.0001 |
| College grad. | 0 | 38 (29%) | |
| Masters/doctoral | 0 | 2 (2%) | |
| Missing/Unknown | 0 | 7 | |
| Father’s education | |||
| <High school | 1 (8%) | 4 (6%) | |
| High school diploma | 5 (38%) | 21 (34%) | |
| Some college | 1 (8%) | 11 (18%) | 0.75 |
| College grad. | 6 (46%) | 22 (35%) | |
| Masters/doctoral | 0 | 4 (6%) | |
| Missing/Unknown | 20 | 74 | |
| Mother’s education | |||
| <High school | 1 (7%) | 5 (8%) | |
| High school diploma | 2 (14%) | 20 (32%) | |
| Some college | 6 (43%) | 12 (19%) | 0.11 |
| College grad. | 3 (21%) | 24 (38%) | |
| Masters/doctoral | 2 (14%) | 2 (3%) | |
| Missing/Unknown | 19 | 73 | |
| Antibiotic Classes received1 | |||
| Gram Positive Cocci | 31 (94%) | 119 (88%) | 0.29 |
| MRSA | 16 (48%) | 72 (53%) | 0.65 |
| Gram Negative | 33 (100%) | 136 (100%) | -- |
| Pseudomonas | 31 (94%) | 136 (100%) | 0.04 |
| Anaerobes | 96 (58%) | 77 (57%) | 0.67 |
| Patient took ≥1 Broad Spectrum Antibiotic | 30 (91%) | 111 (82%) | 0.20 |
| Patient did not take ≥1 Broad Spectrum Antibiotic | 3 (9%) | 25 (18%) | |
| Other meds taken while on antibiotics | |||
| Mucolytic | 0 | 3 (2%) | 0.52 |
| Steroid | 3 (9%) | 1 (1%) | 0.02 |
| Days from exacerbation (mean (median) ± std dev) to: | |||
| 1st PRO measurement (Index) | 1.0 (1.0) ± 0 | 1.1 (1.0) ± 0.9 | 0.09 |
| 2nd PRO measurement (~Day 7) | 7.2 (7.0) ± 1.4 | 7.4 (7.0) ± 2.4 | 0.37 |
| 3rd PRO measurement (End of PEx treatment) | 15.8 (14.0) ± 6.4 | 17.6 (15.0) ± 6.8 | 0.19 |
| EQ-5D-5L improved2 by the end of antibiotic therapy | 20 (61%) | 85 (63%) | 0.84 |
| CFRSD-CRISS improved3 by the end of antibiotic therapy | 28 (85%) | 108 (79%) | 0.48 |