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. Author manuscript; available in PMC: 2020 Jan 23.
Published in final edited form as: Chem Rev. 2018 Nov 26;119(2):1193–1220. doi: 10.1021/acs.chemrev.8b00285

Figure 1.

Figure 1

Iron availability in macrophages. Macrophages uptake iron by sequestering Tf/Lf bound iron and storing released iron in ferritin nanocages. Heme is either uptaken by Hx and Hp-Hb complex receptors where the proteins are degraded in the endosome, or by erythophagocytosis of senescent red blood cells (RBC). In both cases, heme is released into the macrophage cytosol. There, heme is degraded by heme oxygenase (HO-1) to release iron, carbon monoxide (CO) and biliverdin – discussed in 5.1. Mtb residing in the macrophage phagosome will encounter iron and likely also heme and Hb.