Figure 11.

Heme uptake in Gram-positive S. aureus. Heme is acquired using cell surface receptors that directly interact with and scavenge heme from Hb. Heme is then shuttled across the cell-wall through a series of heme transporters via protein-protein interactions. Heme is finally translocated across the membrane using an ABC transporter and degraded via the IsdG-type heme degraders, IsdG and IsdI, see section 5.3.