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. Author manuscript; available in PMC: 2020 Jan 23.
Published in final edited form as: Chem Rev. 2018 Nov 26;119(2):1193–1220. doi: 10.1021/acs.chemrev.8b00285

Figure 6.

Figure 6

Mtb MmpL family. A. The 13 Mtb MmpL proteins fall into two distinct clusters. B. Mtb MmpL proteins are members of the RND superfamily; PN, PC, D1 and D2 are porter subdomains (green) and DN and DC are docking domains (purple). The 12 TM domain is colored wheat, where red TMs are those involved in proton motive force. C. Cartoon representation of monomeric CusA (PDB: 4DNT) and Phyre2 predictions of MmpL4 (Cluster I) and MmpL3 (Cluster II) structures. The MmpL Cluster II cytoplasmic D3 domain has no structural prediction.