. Author manuscript; available in PMC: 2020 Jan 23.

Published in final edited form as: Chem Rev. 2018 Nov 26;119(2):1193–1220. doi: 10.1021/acs.chemrev.8b00285

Table 3:

Heme binding properties of proposed Mtb heme uptake proteins.

Protein	Coordination	k_on (μM⁻¹s⁻¹)	k_off (s⁻¹)	K_a (M⁻¹)	Ref
Rv0203	5 c O⁻/Tyr	133	0.0082	1.6 × 10⁹	151
Mmp3-D1	5c/6c unknown ligands	29^a	^bk_f: 0.0036 (44%) k_s: 0.0004 (56%)	8.1 × 10⁹	153
MmpL11-D1	5c/6c unknown ligands	53	0.34	1.6 × 10⁹	153
PE22-PPE36	unknown	ND	ND	250	147
PPE62	unknown	ND	ND	2500	147
Rv0265c (FecB2)	unknown	ND	ND	3333	147

on rate refers to ferrous CO-heme binding.

k_f and k_s represent the fast and slow rates of heme dissociation, respectively.

ND = not determined, 5c = 5-coordinate, 6c = 6-coordinate