Table 1.

Natural antioxidants.

Molecule	Natural source	Mechanism of action	Target organ	Molecular target
Resveratrol	Red wine, peanut, grape, pine, blackberry	Anti-proliferative, anti-angiogenic, anti-inflammatory	Ovary, breast, prostate, liver, lung, stomach	P53, glutathione, AKT, NFkB, iNOS, STAT3, Survivina
Lupiol	Mango, olives, strawberry, black grapes	Anti-mutagen, anti-proliferative, anti-apoptotic	Skin, lung, pancreas, colon, prostate, liver	P21, Fas, Bcl-2, Bax, AKT, NFkB, COX-2, NOS,RAS
Betulinic acid	Widespread in the vegetable rank (birch)	Anti-inflammatory, immunomodulatory, anti-apoptotic	Skin, ovary, prostate, lung, breast, kidney, uterine cervix	PPR-g, p21, p38, NFkB, JNK, COX-2
Polynsatured Fatty acids	Corn, sunflower, olives, spinach, walnuts	Anti-apoptotic, anti-inflammatory	Colon, breast, prostate, pancreas, blood tumors	NFkB, Fas/FasL, PPr-g, Bcl-2, ERK1/2, STAT3
Glicolide B	Ginseng	Anti-angiogenic, anti-apoptotic	Ovary, brain, breast	iNOS, JNK
Luteolin	Artichoke, celery, green pepper, broccoli, mint	Anti-inflammatory, anti-allergic, anti-proliferative	Ovary, liver, colon, breast, prostate, skin, pancreas	JNK, p53, IGF-1R, EGFR, BCL-2, STAT3
Lycopene	Tomato, pink grapefruit, papaya	Anti-proliferative, anti-inflammatory, anti-angiogenic	Lung, breast, pancreas, colon	Ciclina D1, Bcl-2, AKT, NFkB

An incomplete list with origin and molecular effects on target organs.