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. 2019 Jun 7;10:1246. doi: 10.3389/fmicb.2019.01246

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Copyright © 2019 Yehuda, Slamti, Malach, Lereclus and Hayouka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Second generation of PapR₇-derived peptide combinations. (A) Sequences of first generation potent synthetic inhibitors 7-mer PapR-derived peptides (PapR₇; ADLPFEF) involved D-amino acid or alanine replacements at three positions; proline (P) glutamic (E), and phenylalanine (F) of the heptapeptide PapR. (B) Sequences of second generation of PapR₇-derived peptide combinations, involved double and triple alanine and D-amino acids replacement.