Table 2.
Median differences and Wilcoxon signed rank statistics for matched pair plan comparisons for conformity indices, gradient index, mean brain dose, and volume of the brain receiving 12Gy, 6Gy, and 3Gy.
| Paired Median Differences and Statistical Significance | |||||
|---|---|---|---|---|---|
| Gamma Knife | HyperArc-VMAT | Manual-VMATA | Manual-VMATB | ||
| Elements | CI-RTOG | −0.35 | −0.46 | −0.46 | −0.50 |
| CI-Paddick | 0.15 | 0.22 | 0.20 | 0.25 | |
| Gradient index | −0.75 | −0.33 | 3.58 | 0.73 | |
| Brain mean dose (cGy) | −82 | −73 | 74 | 19 (p = 0.14) | |
| V12Gy (cc) | −5.5 | −7.8 | 6.4 | −7.0 | |
| V6Gy (cc) | −45 | −52 | 98 | 5.8 (p = 0.4) | |
| V3Gy (cc) | −210 | −210 | 160 | 100 | |
| GammaKnife | CI-RTOG | −0.11 | −0.077 | −0.15 | |
| CI-Paddick | 0.085 | 0.058 | 0.11 | ||
| Gradient index | 0.70 | 4.14 | 1.36 | ||
| Brain mean dose (cGy) | 18 | 140 | 100 | ||
| V12Gy (cc) | −1.3 | 13.0 | −0.12 (p = 0.98) | ||
| V6Gy (cc) | −3.7 | 150 | 56 | ||
| V3Gy (cc) | 36 (p = 0.07) | 370 | 270 | ||
| HyperArc-VMAT | CI-RTOG | 0.0 (p = 0.9) | −0.048 | ||
| CI-Paddick | 0.0 (p = 0.3) | 0.026 | |||
| Gradient index | 4.0 | 0.95 | |||
| Brain mean dose (cGy) | 140 | 90.0 | |||
| V12Gy (cc) | 17 | 1.9 | |||
| V6Gy (cc) | 160 | 65 | |||
| V3Gy (cc) | 390 | 310 | |||
| Manual-VMATA | CI-RTOG | −0.041 | |||
| CI-Paddick | 0.030 | ||||
| Gradient index | −3.0 | ||||
| Brain mean dose (cGy) | −55 | ||||
| V12Gy (cc) | −15 | ||||
| V6Gy (cc) | −92 | ||||
| V3Gy (cc) | −67 | ||||
Median differences are a result of column plan—row plan. All non-bolded cells have statistically significant difference (p < 0.05). P-values that were not statistically significant are bolded and underlined. Blank areas of the table indicate repeat or non-sensical plan combinations.