Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 7;10:638. doi: 10.3389/fphar.2019.00638

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Li, Li, Jia, Sun, Zhou, Jin and Mao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Baicalein counteracts FeCl₃-induced epileptic seizure behavior by inhibiting ferroptosis. (A) Decreased seizure score after treatment with Lipo-1 (a specific inhibitor of ferroptosis) in the FeCl₃-induced PTE model. (B) Western blots showing expression of 4-HNE in hippocampus tissues of FeCl₃-induced PTE mice with different doses of baicalein and Lipo-1 pretreatment, n = 6. (C) The relative mRNA expression of PTGS2 was reduced after baicalein and Lipo-1 pretreatment, n = 6. (D) Western blots illustrated that GPX4 was significantly diminished in FeCl₃-induced PTE mice, and baicalein and Lipo-1 treatment reversed this phenomenon (n = 6 for both groups). (E) Baicalein inhibited the increase of 12/15-LOX in hippocampus tissues from FeCl₃-induced PTE mice, n = 6. *p < 0.05, **p < 0.01, and ***p < 0.001.