Table 4:
Selected examples of detected ingredient-AE signals, their labels, scores, and the corresponding adverse events in the NMCD ingredient monograph.
| Detected Ingredient - Adverse Event | Label | PRR (PRR05) | ROR (ROR05) | BCPNN (IC025) | GPS (EB05) | Corresponding adverse event term in NMCD monograph |
|---|---|---|---|---|---|---|
| Tomato - Abdominal pain | P | 3.891 (0.865) | 4.042 (0.877) | 3.882 (0.708) | 3.882 (2.049) | Abdominal pain |
| Caffeine - Heart rate abnormal | P | 8.256 (1.406) | 8.287 (1.407) | 7.977 (0.931) | 7.977 (2.687) | Tachycardia |
| Free plant sterols - Prostate cancer | N | 7.714 (1.341) | 7.749 (1.342) | 7.517 (0.890) | 7.517 (2.365) | AE not in monograph |
| Hesperidin - Alopecia | N | 3.809 (0.935) | 4.044 (0.962) | 3.801 (0.828) | 3.801 (2.473) | AE not in monograph |
| Boron - Hemorrhage | I | 7.427 (1.768) | 7.628 (1.787) | 7.159 (1.686) | 7.159 (5.615) | Hematemesis |
| Cocoa - Urticaria | I | 5.226 (1.100) | 5.420 (1.110) | 5.211 (0.861) | 5.211 (2.596) | Allergic skin reactions and rash |
| Green tea- dehydration | I | 4.753 (1.043) | 4.894 (1.053) | 4.735 (0.855) | 4.735 (2.588) | Diuretics |
| Zinc - Blood urine present | I | 4.091 (1.262) | 4.159 (1.276) | 3.818 (1.193) | 3.818 (3.359) | Acute renal tubular necrosis and interstitial nephritis |
| Pygeum - Dysuria | C | 54.591 (3.342) | 61.087 (3.375) | 54.041 (1.775) | 54.041 (7.782) | People use this for dysuria |
| Selenium - Urinary retention | C | 4.837 (1.231) | 4.855 (1.233) | 4.516 (1.117) | 4.516 (3.230) | People us this for Benign Prostatic Hyperplasia (BPH) |