Scheme 1.
(a) Schematic diagram of the synthetic production of MPBZs. MPBZs modified with PVP were constructed via a simple but efficient strategy: mixing the manganese source solution with PVP and an [Fe(CN)6]4- source with PVP under magnetic stirring. (b) Neutrophils are the principal source of ROS during the inflammatory process. These cells produce •O2- from NOX and NO• from inducible nitric oxide synthase (iNOS). H2O2 and Cl- are produced by the MPO enzyme, which leads to the production of hypochlorous acid (HOCl). Both MPO and HOCl cause lipid peroxidation and tissue damage. Orally administered MPBZs preferentially adhere to the colonic mucosa through size- and charge-mediated targeting motifs in DSS-induced colitis. Given their excellent size- and charge-mediated targeting motifs, MPBZs have significant therapeutic efficacy in mice with DSS-induced colitis via scavenging ROS and inhibiting proinflammatory cytokines.