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. 2019 May 4;9(10):2897–2909. doi: 10.7150/thno.33534

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© Ivyspring International Publisher

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(A) DOX and (B) Cour6 uptake after treatment with BV/Cour6@Au@PDA/DOX by FCM analysis of HeLa cells. Cell viability of HeLa cells incubated with (C) different incubation time of BV@Au@PDA/DOX and BV/PTX@Au@PDA/DOX, (D) and (E) different concentrations of PTX and DOX treated with free drug and BV/PTX@Au@PDA/DOX without and with laser irradiation (*P < 0.05, **P < 0.01 compared with free drug group). (F) Cell viability of HeLa cells incubated with different groups 1: control, 2: BV/PTX, 3: BV/PTX@Au, 4: BV/PTX@Au with laser irradiation, 5: BV@Au@PDA/DOX, 6: BV@Au@PDA/DOX with laser irradiation, 7: BV/PTX@Au@PDA/DOX and 8: BV/PTX@Au@PDA/DOX with laser irradiation. (*P < 0.05, **P < 0.01, ***P<0.001 compared with control group). (G) Representative fluorescence images of HeLa cells internalization of BV/Cour6@Au@PDA/DOX after incubation for 24 hours. Cell nucleus was stained in blue (Hoechst), DOX was displayed in red and Cour6 was shown in green (Scale bar: 20 m). (H) Fluorescence micrographs of HeLa cells treated with different formulations (stained by FDA/PI, green for live and red for dead, Scale bar: 100 m). The data are presented as the mean S.E. (n = 3)

Inline graphic — (A) DOX and (B) Cour6 uptake after treatment with BV/Cour6@Au@PDA/DOX by FCM analysis of HeLa cells. Cell viability of HeLa cells incubated with (C) different incubation time of BV@Au@PDA/DOX and BV/PTX@Au@PDA/DOX, (D) and (E) different concentrations of PTX and DOX treated with free drug and BV/PTX@Au@PDA/DOX without and with laser irradiation (*P < 0.05, **P < 0.01 compared with free drug group). (F) Cell viability of HeLa cells incubated with different groups 1: control, 2: BV/PTX, 3: BV/PTX@Au, 4: BV/PTX@Au with laser irradiation, 5: BV@Au@PDA/DOX, 6: BV@Au@PDA/DOX with laser irradiation, 7: BV/PTX@Au@PDA/DOX and 8: BV/PTX@Au@PDA/DOX with laser irradiation. (*P < 0.05, **P < 0.01, ***P<0.001 compared with control group). (G) Representative fluorescence images of HeLa cells internalization of BV/Cour6@Au@PDA/DOX after incubation for 24 hours. Cell nucleus was stained in blue (Hoechst), DOX was displayed in red and Cour6 was shown in green (Scale bar: 20 m). (H) Fluorescence micrographs of HeLa cells treated with different formulations (stained by FDA/PI, green for live and red for dead, Scale bar: 100 m). The data are presented as the mean S.E. (n = 3)