Table 4.
Results of linear regression analysis assessing the association between CSF levels of NPTX2 and resting-state functional connectivity in the salience/ventral attention network.
| Variable | Estimate | SE | p-value |
|---|---|---|---|
| Age | 0.038 | 0.163 | 0.817 |
| Sex – Male | 0.052 | 0.175 | 0.767 |
| Race – White | −0.670 | 0.440 | 0.131 |
| APOE e4 – Carrier | −0.298 | 0.326 | 0.363 |
| CR composite score | 0.315 | 0.170 | 0.067 |
| Diagnostic status | 0.216 | 0.293 | 0.463 |
| NPTX2 | 1.803 | 0.711 | 0.013 |
| NPTX2 × CR | −0.383 | 0.159 | 0.017 |
| NPTX2 × APOE-e4 | 0.089 | 0.178 | 0.620 |
| NPTX2 × Age | −1.617 | 0.706 | 0.024 |
CSF, cerebrospinal; CR, cognitive reserve.