Table 2.

Change in AUC (ΔAUC*), two-category NRI(p)^a, and three-category NRI(p/2, 2p) as a function of initial model discrimination (AUC) and effect size (Cohen’s D) of an added marker

Baseline		Cohen’s D
AUC		0.2	0.5	0.8
0.65	ΔAUC	0.009	0.049	0.103
	NRI(p)	0.014	0.074	0.157
	NRI(p/2, 2p)	0.032	0.181	0.392
0.75	ΔAUC	0.005	0.027	0.061
	NRI(p)	0.007	0.043	0.100
	NRI(p/2, 2p)	0.019	0.108	0.247
0.85	ΔAUC	0.002	0.013	0.031
	NRI(p)	0.004	0.025	0.060
	NRI(p/2, 2p)	0.010	0.059	0.141

AUC, area under the receiver operating characteristics curve; NRI, net reclassification index.

^aValues of ΔAUC and NRI(p) are true for any event rate p; three-category NRI(p/2, 2p) calculated at P = 0.10.