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. 2019 Jun 7;9:480. doi: 10.3389/fonc.2019.00480

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Copyright © 2019 Sarmiento-Salinas, Delgado-Magallón, Montes-Alvarado, Ramírez-Ramírez, Flores-Alonso, Cortés-Hernández, Reyes-Leyva, Herrera-Camacho, Anaya-Ruiz, Pelayo, Millán-Pérez-Peña and Maycotte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Basal, TNBC cell lines are dependent on ROS for survival. (A) Cells were treated with oxidating conditions (H₂O₂) or with an antioxidant (NAC, N-acetyl cysteine) at the indicated concentrations. One hundred micromolar H₂O₂ treatment increased the ROS^high or decreased the ROS^low population and 30 mM NAC had the opposite effect in all breast cancer cell lines studied. (B,C) Cell death was evaluated as propidium iodide staining [% confluency of PI(+) cells] and normalized to total % confluency. (D) Cell proliferation was evaluated as changes in cell confluency in an Incucyte real time cell imaging system. Graphs show mean ± SEM of more than 3 independent experiments. *different to control, p < 0.05; **different to control, p < 0.01; and ***different to control, p < 0.001.