Table 1.
Breast cancer subtypes show differences in the expression level of mitochondria-related genes.
| Normal-like | Luminal A | Luminal B | HER2-enriched | Basal-like | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Mean ± SD | ANOVA | Mean ± SD | ANOVA | Mean ± SD | ANOVA | Mean ± SD | ANOVA | Mean ± SD | ANOVA | |
| Fusion | OPA1 | −0.25 ± 0.9 | −0.244 ± 0.96 | 0.34 ± 1.3 | 1 | 0.978 ± 1.3 | 0,1,2 | 1.303 ± 1.5 | 0,1,2 | ||
| MFN1 | −0.74 ± 1.18 | −0.015, 1.15 | 0.516 ± 1.2 | 1 | 0.617 ± 1.4 | 0,1 | 1.117 ± 1.5 | 0,1,2 | |||
| MFN2 | −0.17 ± 0.82 | −0.124 ± 1.08 | −0.54 ± 1.3 | 1 | −0.57 ± 1.4 | −0.56 ± 1.4 | |||||
| Fission | DNM1L | −0.62 ± 1.04 | −0.302 ± 1.03 | 0.276 ± 1.1 | 1 | 0.293 ± 1.2 | 1 | 1.023 ± 1.5 | 0,1,2,3 | ||
| MTP18/MTFP1 | −0.28 ± 0.86 | −0.585 ± 1.05 | −0.01 ± 1.1 | 1 | 0.201 ± 1 | 1 | 0.235 ± 1.1 | 1 | |||
| YME1L1 | −0.79 ± 1.77 | −0.204 ± 1.1 | 0.378 ± 1.1 | 1 | 0.2 ± 1.4 | 0.843 ± 1.9 | 0,1 | ||||
| MID51/MIEF1 | −0.38 ± 0.75 | −0.681 ± 1.05 | −0.56 ± 1.3 | 0.297 ± 1.4 | 1,2 | 0.629 ± 1.2 | 1,2 | ||||
| MARCH5 | −1.47 ± 1.25 | −0.14 ± 0.87 | 0 | −0.09 ± 1.1 | 0 | 0.142 ± 1.3 | 0 | −0.43 ± 1.3 | 3 | ||
| MFF | −0.29 ± 1.26 | −0.119 ± 1.01 | −0.23 ± 1 | −0.17 ± 1.2 | 0.071 ± 1.3 | ||||||
| FIS1 | −0.61 ± 1.13 | 0.25 ± 0.97 | 0.151 ± 1.1 | −0.44 ± 1 | 1,2 | −0.82 ± 1 | 1,2 | ||||
| OMA1 | −0.29 ± 0.87 | 0.241 ± 0.95 | 0.115 ± 1.1 | −0.66 ± 1.3 | 1,2 | −0.56 ± 1 | 1,2 | ||||
| MID49/MIEF2 | −0.49 ± 0.79 | 0.11 ± 0.95 | −0.28 ± 1.1 | −0.39 ± 0.8 | 1,2 | −1.24 ± 1 | 1,2,3 | ||||
| Mitophagy | BNIP3L | −0.5 ± 1.09 | −0.084 ± 1.06 | −0.76 ± 1.1 | 1 | −0.75 ± 1.2 | 1 | −1.33 ± 1.1 | 1, 2, 3 | ||
| PINK1 | 0.153 ± 0.93 | 0.146 ± 0.92 | −0.44 ± 1 | 1 | −0.51 ± 1 | 1 | −0.84 ± 1.1 | 1 | |||
| PARK2 | −0.5 ± 1.09 | −0.084 ± 1.06 | −0.76 ± 1.1 | 1 | −0.75 ± 1.2 | 1 | −1.33 ± 1.1 | ||||
| Biogenesis | PPARGC1A | 0.388 ± 0.39 | −0.066 ± 0.7 | −0.51 ± 0.7 | 1 | 0.278 ± 1 | 2 | 0.961 ± 1.6 | 1,2,3 | ||
| PPARGC1B | 0.395 ± 0.87 | −0.285 ± 0.84 | −0.16 ± 1 | 0.531 ± 1 | 1,2 | 1.001 ± 0.9 | 1,2,3 | ||||
| Other | SIRT3 | −1.04 ± 0.7 | 0.382 ± 0.93 | 0 | −0.06 ± 1.1 | 0, 1 | −0.82 ± 0.9 | 1,2 | −1.4 ± 0.9 | 1,2,3 |
mRNA expression z-scores (microarray) analyses from TGCA samples according to their breast cancer sybtype (PAM50 classification). Gray cell means differences with p < 0.05 to Normal-like (0), Luminal A (1), Luminal B (2), or HER2 (3).