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. Author manuscript; available in PMC: 2020 May 29.
Published in final edited form as: J Am Chem Soc. 2019 May 15;141(21):8574–8583. doi: 10.1021/jacs.9b02637

Table 4.

1,3-Disubstituted Enyne Scope for Trisubstituted Allene Synthesisa

graphic file with name nihms-1033391-t0014.jpg
entry product, R1, R2 yield (%)b
1 6a, Ph, Me 60
2 6b, Ph, n-C6H13 66
3 6c, Ph, Cy 51
4 6d, Ph, CF3 60
5 6e, Cy, Me 82
a

Reactions under N2 with 0.2 mmol of tetrahydroisoquinoline (0.8 M).

b

Isolated yields of purified products.