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. 2019 May 28;10:509. doi: 10.3389/fgene.2019.00509

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Copyright © 2019 Mnika, Mazandu, Jonas, Pule, Chimusa, Hanchard and Wonkam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Profiles of Hydroxyurea-induced miRNA expression in selected SCD patients. Panel (A). Heatmap of the miRNA expressing profile for patients that are under HU and off HU in the cross-sectional analysis. Panels (B,C). miRNA expressing profile for patients that are under HU and out of HU, excluding the relapsed patient in pair-wire analysis of patients GS01 and GS04. Using the paired Wilcoxon rank test, we found a significant difference between expression profiles of the two states (p = 0.032e-2), with distinctive micro-RNAs differentially over or expressed in patients GS01 (Panel B1) and GS04 (Panel B3), as shown in the heat map (Panel B2) and the kernel density distributions (Panel B4) plots. Panel (C). miRNA expression levels of 29 miRNA that are over or under-expressed in GS04-HU vs. GS01. Panel (D). Networks linked to over and under expressed miRNA under HU treatment. In the figure 13 miRNAs target mainly 4 genes BCL11A, MYB, KLF3, and SP1, that belong to the same network and influence erythropoiesis and HbF expression.