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. 1997 Aug 15;17(16):6075–6085. doi: 10.1523/JNEUROSCI.17-16-06075.1997

Fig. 5.

Fig. 5.

Pharmacological profile of agonist-induced currents and IPSCs. A, Left, The effect of various blockers on the currents induced by bath application of 20 μm GABA (two cells were studied for each blocker).Right, The effects of these blockers on the currents elicited by bath application of 50 μm glycine (number of cells included: three for 3 μm bicuculline, one for 3 μm SR95531, four for 0.3 μm strychnine, and one for 10 μm bicuculline). B, Pooled data on the effect of various blockers on the synaptic activity, studied as the sum of all events detected per unit of time (see GABAergic IPSCs). Four cells were studied in each group. The error bars inA and B correspond to the SEM, calculated for groups in which n ≥ 3. C, Display of the effects of bicuculline and strychnine on the IPSCs recorded from another RGC, which had a mixed population of IPSCs. Holding potential, −60 mV. In this cell the GABAAinhibitor bicuculline produced a 40% block of IPSCs; the remaining activity was abolished by 0.3 μm strychnine.