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. 1997 Aug 15;17(16):6243–6255. doi: 10.1523/JNEUROSCI.17-16-06243.1997

Fig. 1.

Fig. 1.

GGF2 induces SC migration and accelerates AChR cluster dispersal in denervated neonatal muscles. Low-magnification view of SCs, labeled with anti-s100, in (A) a normally innervated P9 muscle and (B) a P9 soleus muscle denervated on P4 and exposed daily for 5 d to exogenous GGF2. Terminal SCs in the GGF2-treated, denervated muscle were no longer clustered over endplates as in the control muscle but had migrated and extended processes. The processes grew primarily in an orientation parallel to the muscle fibers. Muscle fibers extend from top to bottom in A and B.C–E, AChR plaques labeled with rhodamine-conjugated BTx in a normally innervated P9 soleus muscle (C), a P9 soleus muscle denervated on P4 and exposed daily for 5 d to exogenous GGF2 (D), and a P9 soleus muscle denervated on P4 and examined 5 d later (E). Muscle fibers extend diagonally in C–E. Scale bar (shown inA): 100 μm; (shown in C): 20 μm.