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. 1997 Aug 15;17(16):6243–6255. doi: 10.1523/JNEUROSCI.17-16-06243.1997

Fig. 4.

Fig. 4.

Synaptic efficacy is decreased in GGF2-treated muscles before changes in postsynaptic AChR density.A, Superimposed intracellular records of epps obtained during nerve stimulation in a P16 muscle treated with GGF2 for the previous 5 d. The epps were subthreshold and frequently failed. A spontaneous potential (mepp) recorded from the same fiber is shown in the inset. Calibration: 4 mV, 10 msec. B, Mepp frequency in GGF2-treated muscles (open bars) was greatly reduced relative to controls (filled bars). Fibers in which there were 0 mepps/min were counted only if we could elicit epps with fast rise times on soleus nerve stimulation, indicating that we were recording from the vicinity of the endplate. C, BTx labeled AChR clusters at endplates in a P16 control muscle, (D) a P16 muscle treated with GGF2 for the previous 5 d, and (E) a P16 muscle that had been denervated for 5 preceding days. Scale bar, 20 μm.