Fig 8. B6-derived Idd10 region in myeloid cells as well as T cells provides the greatest degree of protection from T1D.
The frequency of T1D was assessed by the analysis of urinary glucose concentration in NOD Idd10 scid and NOD.B6 scid recipients upon transfer of 5x107 T cells from 6-8-week-old CD101+/+ NOD.B6 Idd10 (A) or CD101−/− NOD.B6 Idd10 mice (B). The indicated numbers of female recipients in each cohort were analyzed until day 100 after the adoptive T cell transfer. Kaplan–Meier survival curves were plotted for each mouse strain, and statistical significance was determined by log rank test (*, p<0.05).