Fig 5. Amounts of β-1 and β-3 integrins determine ligand binding, traction stress, and adhesion stability.

(A) Percentage of ligand-bound integrins by varying fraction of β-1 in a system of β-3 integrins, as a function of actin flow speed. (B) Average tension per integrin varying actin flow speed and percentage of simulated β-1 in a system of β-3 integrins. (C) Average distance between nearest ligand-bound integrins, without distinction between β-1 and β-3 integrins. Represented are regions of unstable and stable adhesions, depending upon the minimum spatial separation between any integrin type. Data are computed as averages between 1–120 s of simulations.