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. 2019 Jun 14;14(6):e0218449. doi: 10.1371/journal.pone.0218449

Fig 2. AdoK is responsible for mycobacterial sensitivity to cordycepin.

Fig 2

(A) Mutant strain CR01-S115L is resistant to cordycepin. Mycobacterial strains were grown in 7H9 medium containing 0, 0.08, 0.16, 0.32, 0.64, or 1.28 mM cordycepin at 37°C for 9 days. Their CFUs were then determined and indicated in the figure. Both wildtype BCG/WT and the complemented strain CR01-S115L/pMV261-adoK are sensitive to cordycepin. (B) Assays for the sensitivities of adoK-deleted and its complemented strains to cordycepin. The mycobacterial strains were grown in 7H9 medium containing 0 (control), 0.16, 0.32, and 0.64 mM cordycepin at 37°C for 9 days, and CFUs were measured. All error bars in the figures represent the standard deviations (SD) of the data derived from three biological replicates.