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. Author manuscript; available in PMC: 2020 Jan 14.
Published in final edited form as: Cancer Cell. 2018 Dec 27;35(1):140–155.e7. doi: 10.1016/j.ccell.2018.11.015

Figure 3. Active PDGFRα Mutant Cooperates with Trp53 Deficiency to Accelerate High-Grade Glioma Formation.

Figure 3.

(A) Kaplan-Meier survival analysis in mice with induced mutant PDGFRA (n = 10), p53cKO (n = 46), or PDGFRA;p53cKO (n = 46), *p < 0.0001. (B) Location of macroscopic brain tumors for cohorts shown in (A): Supra, Supratentorial; CB, Cerebellar; Spinal, Spinal cord; BS, Brainstem. p53cKO cohort same as in Figure 2B. (C) HGG in PDGFRA;p53cKO mice. Sagittal section immunostained with anti-human PDGFRα (top image), and higher magnification of the pons for H&E stain and IHC of PDGFRα, Olig2 and H3K27me3 in representative HGG. Scale bar = 1 mm (whole brain image), 50 μm (higher magnification images). See also Figure S4.