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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: DNA Repair (Amst). 2019 May 7;79:40–49. doi: 10.1016/j.dnarep.2019.05.002

Figure 2: Human G1/S Transition and Replication Stress Response.

Figure 2:

A) Prior to S-phase, E2F transcription is inhibited by Rb binding. Upon entrance to S-phase, G1 cyclin/CDK complex phosphorylates Rb, releasing E2F1 to permit transcription. E2F6 then inhibits transcription of G1/S targets. B) Upon replication stress, ATR activates Chk1 to phosphorylate E2F6, promoting the transcription of E2F1 targets.