Skip to main content
. 2019 Jun 11;10(39):3939–3951. doi: 10.18632/oncotarget.27003

Figure 1. Human CNOT3 E to K mutations in cancer.

Figure 1

(A) Schematic representation of CNOT3 protein showing the numerous mutations throughout the CNOT3 amino acid sequence in cancers. The two most common missense mutations are E20K and E70K, which occur in the Not3 domain (green box) and are the two mutations that we discovered during FAP adenoma sequencing experiments [13]. (B) Percentage of E to K mutations compared to total missense mutations in the twelve CCR4-NOT supercomplex subunits over all cancer samples in the cBIOPORTAL database. CNOT3 is presented in red.