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. 2019 Jun 14;5(6):eaaw9562. doi: 10.1126/sciadv.aaw9562

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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

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Fig. 1 — (A) The design of PTMAO is derived from TMAO, a zwitterionic osmolyte in saltwater fishes. The nonfouling property of PTMAO could effectively prevent a surface from biofouling both in vitro and in vivo. (B) Scheme of TMAO monomer and polymer synthesis.