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. Author manuscript; available in PMC: 2019 Jul 30.
Published in final edited form as: Lab Invest. 2019 Jan 30;99(6):764–776. doi: 10.1038/s41374-018-0178-5

Figure 4. Lack of α-CGRP reduces BDL-induced cellular senescence.

Figure 4

[A] Cellular senescence was enhanced in BDL WT mice compared to WT mice but reduced in BDL α-CGRP−/− mouse liver compared to BDL WT mice, which was verified by SA-β-gal staining in liver sections (n=4, Orig., magnification, 40×; scale bar=100μm). [B-C] The mRNA expression of [B] p16, p21 and CCL2 and PAI-1 as well as [C] p16 protein levels were increased in total liver from BDL WT mice compared to WT mice but decreased in total liver from BDL α-CGRP−/− mice compared to BDL WT mice (n=3). *p<0.05 vs. WT mice; #p<0.05 BDL WT mice.