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. Author manuscript; available in PMC: 2019 Jul 30.
Published in final edited form as: Lab Invest. 2019 Jan 30;99(6):764–776. doi: 10.1038/s41374-018-0178-5

Figure 6. Lack of α-CGRP decreases fibrosis gene expression and increases senescence marker expression in HSCs from BDL mice.

Figure 6

[A] The mRNA expression of Col1α1 was decreased in HSCs isolated from BDL α-CGRP−/− mice compared to BDL WT mice (n=3). [B] The p16 and p21 mRNA expression was increased in BDL α-CGRP−/− mice compared to BDL WT mice (n=3). [C] Immunofluorescent staining showed that p16 protein expression was decreased in HSCs from BDL WT mice compared to BDL α-CGRP−/− mice (n=3, Orig. magnification, 40×, scale bar= 25 μm). #p<0.05 vs. BDL WT mice.