Skip to main content
. Author manuscript; available in PMC: 2019 Jul 30.
Published in final edited form as: Lab Invest. 2019 Jan 30;99(6):764–776. doi: 10.1038/s41374-018-0178-5

Figure 8. Effect of stimulation with cholangiocyte supernatant on fibrosis and senescence gene expression in HHSCs.

Figure 8

[A-C] The mRNA expression of [A] TGF-β1, [B] TIMP1 and [C] Fn1 increased in HHSCs stimulated with cholangiocyte supernatant from BDL WT mice compared to HHSCs stimulated with cholangiocyte supernatant from WT mice but decreased in HHSCs treated with cholangiocyte from BDL α-CGRP−/− mice compared to HHSCs stimulated with cholangiocyte supernatant from BDL WT mice (n=4). [D-F] The mRNA expression of [D] p16, [E] p18 and [F] p21 was increased in HHSCs treated with cholangiocyte supernatant from BDL α-CGRP−/− mice compared to HHSCs stimulated with BDL cholangiocyte supernatant (n=4). *p<0.05 vs. HHSCs treated with cholangiocyte supernatant from WT mice; #p<0.05 vs. HHSCs treated with cholangiocyte supernatant from BDL WT mice.