Skip to main content
. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: J Cell Biochem. 2019 Feb 25;120(8):12450–12460. doi: 10.1002/jcb.28512

Figure 5. Schematic of proposed effect of M-CSF on bone marrow OCP development and OC differentiation.

Figure 5.

OC, share a common progenitor with macrophages, and develop sequentially from c-Kit+ cells via c-Kit+CD11b+ cells to c-Kit-CD11b+ cells and then to pre-OC. M-CSF promotes macrophage development of early myeloid progenitors at the expense of OCP expansion, while promoting late OC progenitor development and OC differentiation.