Figure 5: Increasing central serotonin with 5-HTP modulates social attention.

A) Baseline differences in how long rhesus macaques look at social and non-social images are negatively correlated with the differences in how 40mg/kg 5-HTP changes looking duration to social and non-social images relative to saline (blue dashed line). Each shape represents an individual subject’s data. B) The average differences in the changes in looking duration to social and non-social images due to 5-HTP for low and high baseline animals. The inset shows the raw looking duration to social (filled bars) and non-social images (open bars) for low and high baseline animals during saline (blue) and 5-HTP (red) sessions. Adapted and reproduced with permission from(Weinberg-Wolf et al., 2018). C) Average time courses of 5-HTP’s bi-directional effect on attention to the mouth for low and high baseline animals. 5-HTP increases attention to the mouth region in low baseline animals but decreases it in high baseline animals. Saline data shown in blue, and 40mg/kg 5-HTP in red. Adapted and reproduced with permission from(Weinberg-Wolf et al., 2018). D) Average time courses of 5-HTP’s effect on attention to conspecific eyes for low and high baseline animals. While 5-HTP has a large effect on attention to the mouth, it only modestly increases attention to the eye region in low baseline animals while modestly decreases it in high baseline animals. Saline data shown in blue and 40mg/kg 5-HTP in red. Adapted and reproduced with permission from(Weinberg-Wolf et al., 2018).