Fig. 2.

The effects of 25I-NBOMe on extracellular levels of DA, 5-HT, and GLU measured in the rat frontal cortex and head-twitch response induced by the drug. Panel a shows the total effects expressed as an area under the curve (AUC) of the percent of each basal level. Panel b shows the number of head twitches counted for 240 min starting immediately after injection. Values are the mean ± standard error of the mean (SEM) (n = 6 per experimental groups). “a” P < 0.01 vs. control group; “b” and “c” P < 0.01 show significant difference vs. 3 and 0.3 mg/kg 25I-NBOMe, respectively (one-way ANOVA and Tukey’s post hoc test)