Table 7.

28-day mortality using multivariable analysis

Variable	OR (95% CI)	P value
Early appropriate antibiotic treatment	0.096 (0.011–0.846)	0.035
Age	1.077 (0.996–1.164)	0.062
Limitation of level of care	8.684 (1.330–56.690)	0.024

A logistic regression with 28-day mortality as dependent variable was performed. Stepwise removal of the parameter with the highest P value in the univariate analysis rendered a three-variable model with the parameters age, early appropriate antibiotic treatment and limit of level of care giving the best fit. P values < 0.05 were considered statistically significant in the multivariable analysis and are shown in italics. To fulfil the criterion “early appropriate antibiotic treatment,” the 1st dose must have been adequate and administered within 1 h, and the 2nd dose given with less than 25% delay after the recommended interval