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. 2019 Jun 14;38:259. doi: 10.1186/s13046-019-1262-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The biological function of NF-kB/miR-130b~301b/USP13 axis in vitro. a-e. NF-kB p65 was overexpressed in BC cells by transfecting with pLvx-NF-kB p65, then followed by transfection of antagomir of miR-130b/301b or USP13 overexpression. Cell proliferation index was determined by CCK-8 assay and cell colony formation assay. Each group was indicated as: 1 empty vector; 2 NF-kB p65 overexpression; 3 NF-kB p65 overexpression with miR-130b knockdown; 4 NF-kB p65 overexpression with miR-301b knockdown; 5 NF-kB p65 overexpression with restoration of USP13 expression. f-h. Cell invasive and migrative capacities were determined by Transwell assay. The cells were grouped as described in (a). Original magnification: 400×. *P < 0.05 and **P < 0.01, as determined by Student’s T-test