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. 2019 Jun 14;38:259. doi: 10.1186/s13046-019-1262-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Mechanistic diagram illustrates the signaling transduction of NF-kB/miR-130b~301b cluster/USP13 axis. NF-kB decreases USP13 expression by inducing the transcription of miR-130b/301b, thereby suppresses expression of PTEN. On the other hand, PTEN governs the activity of NF-kB by inhibiting the PI3K/AKT signaling. The regulatory loop of NF-kB-induced loss of PTEN expression promotes constitutive activation of NF-kB and tumorgenesis of bladder cancer