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. 2019 Jun 14;12:302. doi: 10.1186/s13071-019-3542-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — tTG deletion alleviates the severity of Sj-induced hepatic fibrosis. Wild-type (WT) and tTG deficient (tTG-/-) mice were infected with 20 ± 3 cercariae of Sj for 0, 6 and 8 weeks. a Typical Sj single egg granuloma stained by Sirius red (200×, scale-bar: 50 μm) is shown on the left panel. The percentage of morphometric collagen areas around Sj single egg was calculated and is shown on the right panel (Mann-Whitney U-test, **P = 0.001, *P = 0.0492). b The protein expression levels of tTG and Col1 in mice liver homogenates detected by Western blotting are displayed on the left panel, and semi-quantitative analysis is shown on the right panel. GAPDH was used as loading control. c The average Sj egg numbers present in each liver section is shown. Data are presented as the mean ± SD from approximately three to six mice per group. All in vitro experiments were performed twice or thrice. Red arrows indicate the Sj eggs (t-test, ns)