Fig. 6.

NSC-exo, but not MN-exo, reduce hippocampal synaptic vulnerability to Aβo binding. Fresh hippocampal brain slices were prepared from male wt mice and treated with NSC-exo or MN-exo for 4 h before being challenged with Aβ oligomers (2.5 μM for 30 min). Synaptosomes were then isolated from each brain slice and the amount of bound Aβ measured using a specific ELISA. N = 3 mice/group, 3 slices/mouse. *p < 0.05; Student’s two-tailed T-test