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. 2019 Jun 14;14:25. doi: 10.1186/s13024-019-0322-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — NSC-exo, but not MN-exo, reduce synaptic vulnerability to Aβo binding in hippocampus neurons in vitro. a) Representative confocal microscope images (40X w/3.2 zoom) showing association of Aβ oligomers (2.5 μm, 30 min; 647-Aβo, red) to hippocampal neurons (βIII-tubulin, green) generated by differentiation of adult rat hippocampus NSC. Nuclei are counterstained blue with DAPI. Calibration bar = 25 μm. b) Quantification of the number of 647-Aβο puncta shown in panel A (N = 12 images acquired from 4 independent experiments). ***p < 0.001; ****p < 0.0001 one-way ANOVA (F = 18.95) followed by Tukey’s multiple comparisons test