Table 1.

Experimental studies that investigated the role of quercetin in ovarian cancer

Form of quercetin	Doses	Type of cervical cancer	Model	Findings	Ref
Quercerin	80 mg/kg twice a week	–	In vivo	Induced apoptosis, induced ER stress, activated p-STAT3/ Bcl2 axis, induced protective authophagy,	[78]
34′7TMQ	–	Epithelial and fibroblast ovarian cancer cell lines	In vitro	Inhibited cell migration and invasion, inhibited expression of uPA and MMP-2	[90]
Quercetin	A dose range	Metastatic ovarian cancer cell line	In vitro	Decreased viability, induced apoptosis, decreased Bcl-2 and Bcl-xL, increased caspase-3, caspase-p, Bid, Bad, Bax, cytochrome c	[79]
Quercetin	100 μM	Multi-drug resistant ovarian cancer cell line	In vitro	Increased ER stress, prolonged DNA repair, increased expression of p53, p21 and Bax, decreased expression of Bcl-2, induced radio-sensitization,	[81]
Quercetin	–	Human ovarian cancer xenograft model	In vivo	increased radiation-induced cell death, increased p53, increased ER stress
Quercetin	A dose range	Cisplatin sensitive and resistant cell lines	In vitro	Enhanced cisplatin cytotoxicity, increased ER stress, suppressed STAT-3 phosphorylation, decreased expression of Bcl-2,	[82]
	40 mg/kg once a week	Human ovarian cancer xenograft model	In vivo	Suppressed STAY-3 phosphorylation, decreased Bcl-2 expression, induced apoptosis
Quercetin	A dose range	Epithelial ovarian cancer cell line and its CIS-resistant cell line	In vitro	Decreased expression of cyclin D1	[85]
Quercetin	A dose range	Epithelial ovarian cancer cell line	In vitro	Inhibited proliferation, induced apoptosis, decreased survivin, induced cell cycle arrest	[86]
Nano-formulation of quercetin	A dose range	Ovarian endometrioid adenocarcinoma	In vitro	Inhibited growth, induced apoptosis, activated caspase-3 and caspase-9, decreased expression of MCL-1 and Bcl-2, increased expression of Bax	[80]
	A dose range	Human ovarian cancer xenograft model	In vivo	Inhibited growth, induced apoptosis, inhibited angiogenesis
Quercetin	A dose range	Epithelial and drug resistant ovarian cancer cell lines	In vitro	Decreased ROS, increased anti-oxidant enzymes, inhibited apoptosis	[91]
		Human ovarian cancer xenograft model	In vivo	Increased anti-oxidant enzymes expression, reduced ROS, decreased anti-neoplastic drug’s efficacy
Lipo-Que	–	CIS-resistant and CIS-sensitive ovarian cancer cell lines	In vitro	Inhibited proliferation, induced apoptosis, induced cell cycle arrest	[83]
		Human ovarian cancer xenograft model	In vivo	Inhibited tumor growth, inhibited proliferation, induced apoptosis
Quercetin	2 mg / kg	Human ovarian cancer xenograft model	In vivo	Increased TRAIL sensitization, inhibited tumor growth, increased caspase-3, induced apoptosis	[88]
Quercetin	10 microM	Ovarian serous adenocarcinoma	In vitro	Increased TGF beta 1 activity	[89]
Quercetin	A dose range	Metastatic ovarian serous adenocarcinoma	In vitro	Inhibited PI kinase, decreased IP3 levels	[87]