Table 4.
Estimated coefficients of plasma log-transformed PCB and OC pesticide concentrations (μg/L) in relation to 3MS scores
| OC concentrations | Model 1 | Model 2 | ||||
|---|---|---|---|---|---|---|
| β | SE | P-value | β | SE | P-value | |
| PCB congeners | ||||||
| PCB 105 | −0.811 | 0.509 | 0.111 | −0.780 | 0.544 | 0.151 |
| PCB 118 | −1.225 | 0.581 | 0.035 | −1.207 | 0.611 | 0.048 |
| PCB 138 | −1.219 | 0.626 | 0.052 | −1.223 | 0.644 | 0.058 |
| PCB 153 | −1.387 | 0.705 | 0.049 | − 1.449 | 0.727 | 0.046 |
| PCB 156 | −1.509 | 0.755 | 0.046 | −1.586 | 0.780 | 0.042 |
| PCB 163 | −1.501 | 0.699 | 0.032 | −1.602 | 0.724 | 0.027 |
| PCB 170 | −0.830 | 0.691 | 0.230 | −0.908 | 0.708 | 0.200 |
| PCB 180 | −0.521 | 0.688 | 0.448 | −0.611 | 0.707 | 0.390 |
| PCB 183 | −0.948 | 0.611 | 0.121 | −0.968 | 0.629 | 0.124 |
| PCB 187 | −0.149 | 0.580 | 0.797 | −0.215 | 0.601 | 0.721 |
| OC pesticides | ||||||
| β-HCH | −0.751 | 0.590 | 0.203 | −0.699 | 0.606 | 0.249 |
| HCB | −0.737 | 0.519 | 0.156 | −0.644 | 0.541 | 0.233 |
| Oxychlordane | −0.602 | 0.803 | 0.454 | −0.540 | 0.824 | 0.512 |
| cis-nonachlor | −0.044 | 0.585 | 0.940 | + 0.038 | 0.627 | 0.952 |
| trans-Nonachlor | −0.351 | 0.714 | 0.623 | −0.332 | 0.742 | 0.655 |
| p,p’-DDT | −1.717 | 0.468 | < 0.001 | −1.693 | 0.487 | < 0.001 |
| p,p’-DDE | −1.554 | 0.414 | < 0.001 | −1.578 | 0.422 | < 0.001 |
Note: 3MS Modified Mini-Mental State Examination, β beta, BMI body mass index, β-HCH beta hexachlorocyclohexane, HCB hexaclorobenzene, OC organochlorine, PCBs polychlorinated biphenyls, p,p’-DDT, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane; p,p’-DDE, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, SE standard error
Repeated measures regression models with unstructured correlation matrix
Model 1 was adjusted for total lipids and CSHA phase, age, sex, education, and ApoE4
Model 2 was additionally adjusted for BMI, smoking, alcohol drinking, residence area, vascular score, copper, lead, mercury and zinc