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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Chem Rev. 2019 Jan 30;119(4):2954–3031. doi: 10.1021/acs.chemrev.8b00368

Figure 18.

Figure 18.

Peptidylglycine α-hydroxylating monooxygenase (PHM): (i) active center, (ii) reaction catalyzed, and (iii) proposed catalyztic cycle. Note: For C2, it was proposed that a radical cation, located over the three ligands bound to the Cu, was formed.